歯学部

坂上宏 教授

専門分野
薬理学、生化学
主要研究テーマ
リグニン配糖体のシグナル伝達経路、口腔扁平上皮癌細胞を選択的に傷害する物質及び口内炎を抑制する物質の探索、口腔疾患治療薬の開発に関する研究
提供できる教育内容
歯科薬理学、薬物反応機構

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学位
  • 医学博士 1989年11月 昭和大学
  • 薬学博士 1980年3月 東京大学
  • 薬学修士 1977年3月 東京大学
  • 薬学士 1974年3月 東京大学
主な業績又は職務実績等
  • Sakagami H et al., School cafeteria in the world (4) ? University of the Western Cape. New Food Indutry 61 (No. 8): 637-647, 2019 (ISSN: 0547-0277)
  • Sakagami H et al., Recent progress of basic studies of natural products and their dental application. Review. Medicines (Basel). 2018 Dec 25;6(1). pii: E4. doi: 10.3390/medicines6010004
  • Sakagami H et al., Changes in metabolic pro?les of human oral cells by benzylidene ascorbates and eugenol. Medicines 2018, 5(4), 116; https://doi.org/10.3390/medicines5040116
  • Sakagami H et al., Search of neuroprotective polyphenols using the “overlay” isolated method. Molecules 2018, 23, 1840; doi:10.3390/molecules23081840
  • Sakagami H et al., Change in anticancer drug sensitivity during neuronal differentiation of PC12 Cells. In Vivo 32(4):765-770, 2018
  • Sakagami H and Tomomura M, Dental Application of Natural Products. Review. Medicines (Basel). 2018 Feb 14;5(1). pii: E21. doi: 10.3390/medicines5010021
  • Sakagami H et al., Chapter 18. Therapeutic potential of solubilized nanolignin against oral diseases. In Nanostructures for Oral Medicicne (Nanostructures in Therapeutic Medicine Series), ed., Grumezescu AM, Elsevier, ISBN: 978-0-323-47720-8, pp545-576, 2017
  • Sakagami H et al., Quantitative structure-cytotoxicity relationship of chalcones. Anticancer Res 37, 1091-1098, 2017
  • Sakagami H et al., Chapter 6. Applicability of licorice extracts for treatment of oral diseases, evaluated by simplified in vitro assay systems. pp91-106 in "Biological Activities and Action Mechanisms of Licorice Ingredients" (Ed. Sakagami, Intech, ISBN 978-953-51-5195-1 (April, 2017)
  • Sakagami H et al,, Induction of apoptosis in human oral keratinocyte by doxorubicin. Anticancer Res 37(3):1023-1029, 2017
  • Sakagami H et al., Prominent anti-UV activity and possible cosmetic potential of lignin-carbohydrate complex. Review. In Vivo 30(4): 331-339, 2016
  • Sakagami H et al., Synergism of alkaline extract of the leaves of Sasa senanensis Rehder and antiviral agents. In Vivo. 30(4): 421-426, 2016
  • Sakagami H et al., Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxocology Reports 2: 1281-1290, 2015
  • Sakagami H Biological activities and possible dental application of three major groups of polyphenols. J Pharmacol Sci 126: 92-106, 2014.
  • 朝日大学歯学部非常勤講師、 Medicines誌編集長、 第132回日本薬理学会関東部会長