歯学部

坂上宏 教授

専門分野
薬理学、生化学
主要研究テーマ
リグニン配糖体のシグナル伝達経路、口腔扁平上皮癌細胞を選択的に傷害する物質及び口内炎を抑制する物質の探索、口腔疾患治療薬の開発に関する研究
提供できる教育内容
歯科薬理学、薬物反応機構

※スマホで横スクロール表示になります。

学位
  • 医学博士 1989年11月 昭和大学
  • 薬学博士 1980年3月 東京大学
  • 薬学修士 1977年3月 東京大学
  • 薬学士 1974年3月 東京大学
主な業績又は職務実績等
  • Sakagami H et al., Multi-omics analysis of anti-inflammatory action of alkaline extract of the leaves of Sasa sp. J. Clin. Med. 2021, 10, 2100. https://doi.org/10.3390/jcm10102100,
  • Paulino-Gonzalez AD, Sakagami H et al., Biological Properties of the Aggregated Form of Chitosan Magnetic Nanoparticle. In Vivo 34(4):1729-1738, 2020,
  • Takao K, Hoshi K, Sakagami H et al.: Further quantitative structure-cytotoxicity relationship analysis of 3-styrylchromones. Anticancer Res 40 (1): 87-95, 2020.
  • Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N and Sakagami H. In vitro assessment of antitumor potential and combination Effect of classical and molecular-targeted anticancer drugs. Anticancer Res 39(12): 6673-6684, 2019.
  • Sakagami H et al., Recent progress of basic studies of natural products and their dental application. Review. Medicines (Basel). 2018 Dec 25;6(1). pii: E4. doi: 10.3390/medicines6010004,
  • Sakagami H et al., Changes in metabolic profiles of human oral cells by benzylidene ascorbates and eugenol. Medicines 2018, 5(4), 116; https://doi.org/10.3390/medicines5040116,
  • Sakagami H et al., Search of neuroprotective polyphenols using the “overlay” isolated method. Molecules 2018, 23, 1840; doi:10.3390/molecules23081840,
  • Sakagami H et al., Change in anticancer drug sensitivity during neuronal differentiation of PC12 Cells. In Vivo 32(4):765-770, 2018,
  • Sakagami H and Tomomura M, Dental Application of Natural Products. Review. Medicines (Basel). 2018 Feb 14;5(1). pii: E21. doi: 10.3390/medicines5010021,
  • Sakagami H et al., Chapter 18. Therapeutic potential of solubilized nanolignin against oral diseases. In Nanostructures for Oral Medicicneed., Grumezescu AM, Elsevier, ISBN: 978-0-323-47720-8, pp545-576, 2017,
  • Sakagami H et al., Chapter 6. Applicability of licorice extracts for treatment of oral diseases, evaluated by simplified in vitro assay systems. pp91-106 in ""Biological Activities and Action Mechanisms of Licorice Ingredients"" (Ed. Sakagami, Intech, ISBN 978-953-51-5195-1 (April, 2017),
  • Sakagami H et al, Induction of apoptosis in human oral keratinocyte by doxorubicin. Anticancer Res 37(3):1023-1029, 2017,
  • 2020年BBB論文賞、
  • Most-Cited Paper & Review Award日本農芸化学会、
  • 朝日大学歯学部非常勤講師、
  • Medicines誌編集長、
  • 第132回日本薬理学会関東部会長